{"id":59114,"global_id":"www.bas.bg?id=59114","global_id_lineage":["www.bas.bg?id=59114"],"author":"15","status":"publish","date":"2025-10-08 15:26:45","date_utc":"2025-10-08 12:26:45","modified":"2025-10-08 15:26:45","modified_utc":"2025-10-08 12:26:45","url":"https:\/\/www.bas.bg\/?tribe_events=59114","rest_url":"https:\/\/www.bas.bg\/index.php?rest_route=\/tribe\/events\/v1\/events\/59114","title":"\u0410\u043a\u0430\u0434\u0435\u043c\u0438\u0447\u0435\u043d \u0441\u0435\u043c\u0438\u043d\u0430\u0440 \u201e\u0410\u043a\u0442\u0443\u0430\u043b\u043d\u0438 \u043f\u0440\u043e\u0431\u043b\u0435\u043c\u0438 \u043d\u0430 \u043d\u0430\u0443\u043a\u0430\u0442\u0430\u201c.","description":"<p style=\"text-align: justify;\">\u041b\u0435\u043a\u0446\u0438\u044f \u043d\u0430 \u0442\u0435\u043c\u0430 \u201e\u0414\u0438\u0437\u0430\u0439\u043d \u0438 \u043f\u0440\u0438\u043b\u043e\u0436\u0435\u043d\u0438\u044f \u043d\u0430 \u043d\u043e\u0432\u0438 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\u0410\u0421\u041e-\u0438\u0442\u0435 \u0441\u0435 \u0441\u0432\u044a\u0440\u0437\u0432\u0430\u0442 \u0441 \u043a\u043b\u0435\u0442\u044a\u0447\u043d\u043e \u043f\u0440\u043e\u043d\u0438\u043a\u0432\u0430\u0449 \u043f\u0435\u043f\u0442\u0438\u0434 (\u041a\u041f\u041f; cell penetrating peptide \u2013 CPP), \u0447\u0440\u0435\u0437 \u043a\u043e\u0439\u0442\u043e \u043f\u0440\u043e\u043d\u0438\u043a\u0432\u0430\u0442 \u0432 \u043a\u043b\u0435\u0442\u043a\u0430\u0442\u0430 \u2013 \u043a\u0430\u043a\u0442\u043e \u0432 \u0413\u0440\u0430\u043c-\u043e\u0442\u0440\u0438\u0446\u0430\u0442\u0435\u043b\u043d\u0438 \u0438 \u0413\u0440\u0430\u043c-\u043f\u043e\u043b\u043e\u0436\u0438\u0442\u0435\u043b\u043d\u0438 \u0431\u0430\u043a\u0442\u0435\u0440\u0438\u0438, \u0442\u0430\u043a\u0430 \u0438 \u0432 \u0435\u0443\u043a\u0430\u0440\u0438\u043e\u0442\u043d\u0438 \u043a\u043b\u0435\u0442\u043a\u0438. \u041e\u0441\u0432\u0435\u043d \u0440\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u043d\u0438\u044f \u0434\u0438\u0437\u0430\u0439\u043d \u043d\u0430 \u0410\u0421\u041e-\u0438 \u043d\u0438\u0435 \u0438\u0437\u0431\u0438\u0440\u0430\u043c\u0435 \u043a\u043e\u043d\u043a\u0440\u0435\u0442\u043d\u0438 \u0440\u0438\u0431\u043e\u043f\u0440\u0435\u0432\u043a\u043b\u044e\u0447\u0432\u0430\u0442\u0435\u043b\u0438 \u0438 \u0434\u0440\u0443\u0433\u0438\u00a0 \u0438\u0420\u041d\u041a\u0438 \u043a\u0430\u0442\u043e \u043c\u0438\u0448\u0435\u043d\u0438 \u0437\u0430 \u0442\u044f\u0445 \u043f\u043e \u0447\u0438\u0441\u0442\u043e \u0440\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u043d\u0438 \u0431\u0438\u043e\u0438\u043d\u0444\u043e\u0440\u043c\u0430\u0442\u0438\u0447\u043d\u0438 \u043a\u0440\u0438\u0442\u0435\u0440\u0438\u0438 [10].<\/p>\n<p style=\"text-align: justify;\"><strong>\u0411\u043b\u0430\u0433\u043e\u0434\u0430\u0440\u043d\u043e\u0441\u0442\u0438: <\/strong>\u041d\u0430\u0441\u0442\u043e\u044f\u0449\u0438\u0442\u0435 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f \u0432 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u0438\u044f\u0442\u0430 \u043d\u0430 \u043f\u0440\u043e\u0444. \u041f\u0435\u043d\u0447\u043e\u0432\u0441\u043a\u0438 \u0441\u0430 \u043f\u043e\u0434\u043a\u0440\u0435\u043f\u0435\u043d\u0438 \u043e\u0442 \u0433\u0440\u0430\u043d\u0442 KP-06-H63\/1\/13.12.2022, \u0444\u0438\u043d\u0430\u043d\u0441\u0438\u0440\u0430\u043d \u043e\u0442 \u0411\u044a\u043b\u0433\u0430\u0440\u0441\u043a\u0438\u044f \u041d\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u0435\u043d \u0424\u043e\u043d\u0434 \u201e\u041d\u0430\u0443\u0447\u043d\u0438 \u0438\u0437\u0441\u043b\u0435\u0434\u0432\u0430\u043d\u0438\u044f\u201c \u043d\u0430 (BNSF).<\/p>\n<p style=\"text-align: justify;\"><strong>\u00a0<\/strong><\/p>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\"><strong>\u00a0\u041b\u0438\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u0430:<\/strong><\/p>\n<p style=\"text-align: justify;\">\n<ol>\n<li style=\"text-align: justify;\">Penchovsky, R. and M. Traykovska, <em>Designing drugs that overcome antibacterial resistance: where do we stand and what should we do?<\/em> Expert Opin Drug Discov, 2015. <strong>10<\/strong>(6): p. 631-50.<\/li>\n<li style=\"text-align: justify;\">Pavlova, N., D. Kaloudas, and R. Penchovsky, <em>Riboswitch distribution, structure, and function in bacteria.<\/em> Gene, 2019. <strong>708<\/strong>: p. 38-48.<\/li>\n<li style=\"text-align: justify;\">Traykovska, M., K.B. Popova, and R. Penchovsky, <em>Targeting glmS Ribozyme with Chimeric Antisense Oligonucleotides for Antibacterial Drug Development.<\/em> ACS Synth Biol, 2021. <strong>10<\/strong>(11): p. 3167-3176.<\/li>\n<li style=\"text-align: justify;\">Traykovska, et al., <em>Targeting TPP riboswitches using chimeric antisense oligonucleotide technology.<\/em> ACS Applied Bio Materials, 2022. <strong>5<\/strong>(11): p. 5152-5161.<\/li>\n<li style=\"text-align: justify;\">Traykovska, M. and R. Penchovsky, <em>Targeting SAM-I Riboswitch Using Antisense Oligonucleotide Technology for Inhibiting the Growth of Staphylococcus aureus and Listeria monocytogenes.<\/em> Antibiotics (Basel), 2022. <strong>11<\/strong>(11).<\/li>\n<li style=\"text-align: justify;\">Traykovska, M. and R. Penchovsky, <em>Engineering Antisense Oligonucleotides as Antibacterial Agents That Target FMN Riboswitches and Inhibit the Growth of Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli.<\/em> ACS Synth Biol, 2022. <strong>11<\/strong>(5): p. 1845-1855.<\/li>\n<li style=\"text-align: justify;\">Otcheva, L.A., M. Traykovska, and R. Penchovsky, <em>Targeting Bacterial Adenylate Kinase mRNA with a Chimeric Antisense Oligonucleotide for Rational Antibacterial Drug Development.<\/em> Molecules, 2025. <strong>30<\/strong>(16).<\/li>\n<li style=\"text-align: justify;\">Pavlova, N., M. Traykovska, and R. Penchovsky, <em>Targeting FMN, TPP, SAM-I, and glmS Riboswitches with Chimeric Antisense Oligonucleotides for Completely Rational Antibacterial Drug Development.<\/em> Antibiotics (Basel), 2023. <strong>12<\/strong>(11).<\/li>\n<li style=\"text-align: justify;\">Pavlova, N. and R. Penchovsky, <em>Genome-wide bioinformatics analysis of FMN, SAM-I, glmS, TPP, lysine, purine, cobalamin, and SAH riboswitches for their applications as allosteric antibacterial drug targets in human pathogenic bacteria.<\/em> Expert Opin Ther Targets, 2019. <strong>23<\/strong>(7): p. 631-643.<\/li>\n<li style=\"text-align: justify;\">Penchovsky, R., et al., <em>Antisense and Functional Nucleic Acids in Rational Drug Development.<\/em> Antibiotics (Basel), 2024. <strong>13<\/strong>(3).<\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><strong>\u00a0<\/strong><\/p>\n<p>&nbsp;<\/p>","excerpt":"","slug":"59114","image":false,"all_day":false,"start_date":"2025-10-23 17:00:00","start_date_details":{"year":"2025","month":"10","day":"23","hour":"17","minutes":"00","seconds":"00"},"end_date":"2025-10-23 18:00:00","end_date_details":{"year":"2025","month":"10","day":"23","hour":"18","minutes":"00","seconds":"00"},"utc_start_date":"2025-10-23 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